Unveiling the Role of the Cellular Tumor Microenvironment and the Therapeutic Targets it Provides in Cutaneous T-Cell Lymphoma.

Purpose Of Review: Cutaneous T-Cell Lymphoma (CTCL) poses challenges both in diagnosis and prognosis. The purpose of this review is to address the role of profiling immune and non-immune cells in the tumor microenvironment (TME) as it provides information for better diagnosis, prognosis, biomarker discovery, and personalized treatment strategies.

Recent Findings: Recent evidence suggests that the progression of CTCL is closely linked to the Tumor Microenvironment (TME) which comprises various cell types including immune cells, stromal cells, blood vessels, and the extracellular matrix.

Metalloporphyrins in bio-inspired photocatalytic conversions.

Numerous natural systems contain porphyrin derivatives that facilitate important catalytic processes; thus, developing biomimetic photocatalytic systems based on synthetic metalloporphyrins constitutes a rapidly advancing and fascinating research field. Additionally, porphyrins are widely investigated in a plethora of applications due to their highly versatile structure, presenting advantageous photoredox, photophysical and photochemical properties. Consequently, such metallated tetrapyrrolic macrocycles play a prominent role as photosensitizers and catalysts in developing artificial photosynthetic systems that can store and distribute energy through fuel forming reactions.