Publications by authors named "V Niemeier"
Associated with a host of different diseases, pruritus is a cardinal symptom that poses an interdisciplinary diagnostic and therapeutic challenge. Over time, that symptom may progress independently of the initial cause, thus losing its function as a warning sign and turning into a clinically relevant disease of its own. In Germany, approximately 13.
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- Skin-picking disorder is marked by compulsive skin-picking that leads to noticeable skin damage, with individuals making repeated efforts to stop without success.
- It causes significant issues in various aspects of life, including social and professional situations, and cannot be attributed to other emotional or skin conditions.
- The DSM-V recognizes it as a separate impulse-control disorder, often associated with emotional problems, and may require treatment involving both therapists and psychiatrists for severe cases.
Rationale: In mouse models for atopic dermatitis (AD) hypothalamus pituitary adrenal axis (HPA) dysfunction and neuropeptide-dependent neurogenic inflammation explain stress-aggravated flares to some extent. Lately, cholinergic signaling has emerged as a link between innate and adaptive immunity as well as stress responses in chronic inflammatory diseases. Here we aim to determine in humans the impact of acute stress on neuro-immune interaction as well as on the non-neuronal cholinergic system (NNCS).
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