Structure-function studies of a nucleoplasmin isoform from Plasmodium falciparum.

An organized regulation of gene expression and DNA replication is vital for the progression of the complex life cycle of P. falciparum (Pf), involving multiple hosts and various stages. These attributes rely on the dynamic architecture of chromatin governed by several factors, including histone chaperones.

Management of psychological distress in a patient diagnosed with oral squamous cell carcinoma arising from areca nut-induced oral fibrosis.

Patients with oral cancer are more susceptible to emotional and psychological consequences immediately after diagnosis and treatment phase, which may cause depressive disorders. The WHO defines depression as a disorder that lasts at least 2 weeks and is characterised by a person's protracted unhappiness and loss of interest in activities. Patients psychological responses vary widely according to fears of recurrence, coping mechanisms, health beliefs and available financial support.

Expert Opinions on an Optimal Infant Feeding Quantitative Data Framework: A Mixed Methods Delphi-Style Study in the UK.

Background: This study aimed to explore how expert stakeholders involved in research, policy and practice would define an ideal dataset for collecting infant feeding data, to better align efforts to monitor and evaluate breastfeeding across the UK four nations.

Methodology: Using the Delphi method, two phases of consultation were completed with a total of 42 stakeholders. First, qualitative (Round 1) and quantitative (Round 2) surveys were distributed to an interdisciplinary panel of experts, to identify individual-level agreement for key terms and timepoints for data collection relevant to infant age.

Plasmodium berghei HMGB1 controls the host immune responses and splenic clearance by regulating the expression of pir genes.

High mobility group box (HMGB) proteins belong to the high mobility group (HMG) superfamily of non-histone nuclear proteins that are involved in chromatin remodeling, regulation of gene expression, and DNA repair. When extracellular, HMGBs serve as alarmins inducing inflammation, and this is attributed to the proinflammatory activity of box B. Here, we show that Plasmodium HMGB1 has key amino acid changes in box B resulting in the loss of TNF-α stimulatory activity.

Combination Versus Monotherapy for Carbapenem-Resistant Acinetobacter Species Serious Infections: A Prospective IPTW Adjusted Cohort Study.

Introduction: International guidelines recommend definitive combination antibiotic therapy for the management of serious infections involving carbapenem-resistant Acinetobacter (CRAB) species. The commonly available combination options include high-dose sulbactam, polymyxins, tetracyclines, and cefiderocol. Scanty prospective data exist to support this approach.