Publications by authors named "V NICOLELLA"
Objective: People with multiple sclerosis (MS) might experience symptoms that are usually underestimated. Dysphagia should be evaluated within the Expanded Disability Status Scale (EDSS), but clinicians often do not assess it properly. The objectives of this study are as follows: To assess the prevalence of dysphagia in patients with MS utilizing the Swallowing Disturbance Questionnaire (SDQ); to examine the correlation with the EDSS; to investigate the relationship between dysphagia and clinico-demographic characteristics of MS.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the link between blood neurofilament light chain (pNfL) levels and various clinical and demographic factors in 685 MS patients, finding that higher pNfL correlates with increased disability and recent disease activity.
- Higher pNfL levels were also associated with cardiovascular comorbidities, while patients on disease-modifying treatments (DMTs) had lower pNfL levels.
- This research reinforces the potential of pNfL as a valuable biomarker for understanding MS progression and the effects of treatment in both clinical and research settings.
Background: While music-based therapy (MBT) has been shown to improve motor and non-motor features in multiple sclerosis (MS), benefits of tango have never been assessed.
Objective: To evaluate the benefits of tango classes on quality of life (QoL), mood, fatigue, gait, balance, perception of cognitive disorder and sexuality in people with MS.
Methods: 7 participants (age 41.
Article Synopsis
- The study investigates the wearing-off phenomenon in multiple sclerosis (MS) patients treated with ocrelizumab, focusing on its presence and severity in relation to various factors like demographics, immune profiling, and neuroaxonal damage.
- The research included 106 MS patients, finding that 57.6% experienced wearing-off symptoms, which were often cognitive, sensory, and related to balance, with severity linked to higher levels of neurofilament light chain and certain T lymphocyte subpopulations.
- Results indicate that wearing-off is a prevalent issue associated with less effective response to treatment, as evidenced by increased immune system activity and neuroaxonal damage.
Chronic lymphocytic leukaemia (CLL) is characterised by the expansion of a neoplastic mature B cell clone. CLL clinical outcome is very heterogeneous, with some subjects never requiring therapy and some showing an aggressive disease. Genetic and epigenetic alterations and pro-inflammatory microenvironment influence CLL progression and prognosis.
View Article and Find Full Text PDF