Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial.

PI3K-δ inhibitors have shown impressive activity in lymphoid malignancies but have been hampered by autoimmune and infectious toxicities, leading to market withdrawals. We previously demonstrated activity of the PI3K-δγ inhibitor duvelisib in T cell lymphomas (TCLs) that was associated with inflammatory adverse events. As reported here, we conducted a phase 1b/2a study of duvelisib in combination with either romidepsin (n = 66) or bortezomib (n = 32) in patients with relapsed/refractory TCL and found that the addition of romidepsin, but not bortezomib, appeared to increase efficacy while attenuating PI3K inhibitor-driven toxicity.

Synthesis and Characterization of Coordination Compound [Eu(µ-OCH)(btfa)(NO)(phen)]phen with High Luminescence Efficiency.

A high-luminescent, blue-light excitable europium(III) coordination complex, [Eu(µ-OCH)(btfa)(NO)(phen)]phen () {btfa = benzoyl trifluoroacetone, phen = 1,10-phenantroline}, has been synthesized and investigated. The complex was characterized by infrared (IR) and (PL) spectroscopy. The PL emission spectra of powder samples registered in a range of 10.

Heterogeneity of Starved Yeast Cells in IF Levels Suggests the Role of This Protein .

In mitochondria, a small protein IF suppresses the hydrolytic activity of ATP synthase and presumably prevents excessive ATP hydrolysis under conditions of energy deprivation. In yeast , IF homologs are encoded by two paralogous genes: and . expression is known to aggravate the deleterious effects of mitochondrial DNA (mtDNA) depletion.

Attenuated ADP-inhibition of FF ATPase mitigates manifestations of mitochondrial dysfunction in yeast.

Proton-translocating FF ATP synthase (F-ATPase) couples ATP synthesis or hydrolysis to transmembrane proton transport in bacteria, chloroplasts, and mitochondria. The primary function of the mitochondrial FF is ATP synthesis driven by protonmotive force (pmf) generated by the respiratory chain. However, when pmf is low or absent (e.