PROGNOSTIC SIGNIFICANCE OF BLOOD MARKER OF HYPERTROPHY- CARDIOTROPHIN-1 WHEN CARRYING DIFFERENT VARIANTS OF ITS GENE IN MEN WITH ESSENTIAL HYPERTENSION.

Objective: The aim: To improve diagnosis of essential hypertension with left ventricular hypertrophy and chronic heart failure in men citizens of Podillya region in Ukraine by determining the plasma levels of cardiotrophin-1 in patients with different CT-1 gene variants.

Patients And Methods: Materials and methods: A total of 70 men with no signs of cardiovascular disease and 100 patients with essential hypertension were examined. Among those, 50 participants had hypertension and left ventricular hypertrophy.

[Blood lipids, lipid peroxidation and the effect on them of antianginal preparations in ischemic heart disease patients].

The origin and development of ischemic heart disease (IHD) is attended with activation of lipid free-radical oxidation facilitating further advancement of the disease and with decrease of the organism's antioxidant protection. The antianginal drugs which are used in IHD treatment differ in their effect on the blood lipid composition and their peroxidation. beta-Adrenoblocking agents may cause proatherogenic disorders of the blood lipid graph, this increases the risk of IHD advancement.

[The oxidant and antioxidant systems in patients with stable stenocardia and with a history of small- and large-focus myocardial infarcts].

A study was made as well as a comparison of values of the cholesterol (Chs) lipid fractions concentrations, and of those of the lipid peroxidation processes activity (LPP) and the gluthathione antioxidant system (AOS) status in male subjects aged from 45 to 59 years, healthy individuals and patients with stable angina pectoris and myocardial infarction (micro- and macrofocal) during cicatrizing stage (health resort rehabilitation stage). In patients with various forms of IHD total cholesterol is raised as are atherogenic lipoproteins, and atherogenicity index, intensification being noted of LPO along with a considerable decrease in functional potencies of AOS. Similar pattern of changes of LPO and AOS in patients with stable angina pectoris and myocardial infarction (MI) during cicatrization stage certainly warrants correction of these systems not only in acute phase of MI but at the stage of rehabilitation as well.