Hypermethylation of TUSC5 genes in breast cancer tissue.

Aim: Breast cancer (BC) is one of the most common forms of cancer amongst females. Early diagnosis, prognosis and therapy plays crucial role in the survival of patients with breast cancer. The study was aimed on identification of potential markers for early BC diagnostics by means of genome-wide comparative analysis of gene expression in cancer and normal tissue of breast.

Mechanisms of geomagnetic field influence on gene expression using influenza as a model system: basics of physical epidemiology.

Recent studies demonstrate distinct changes in gene expression in cells exposed to a weak magnetic field (MF). Mechanisms of this phenomenon are not understood yet. We propose that proteins of the Cryptochrome family (CRY) are "epigenetic sensors" of the MF fluctuations, i.

[Renal function in white rats after tiroxin injection preceded by blockade of ACE and nitrogen oxide].

Purpose of this work was to study renal function in white rats following a single dose of exogenous tiroxin (T4) on a background of non-selective NO-synthase blocker or inhibition of angiotensin-1 converting enzyme. The experiment was performed with males of outbred white rats (body mass = 140-180 g). Three days prior to T4 injection, the animals drank water solution of captopril (20 mg/l) or were injected intra-gastrically with water solution of non-selective NO-synthase blocker N(omega)-NLA (1 mg/100 g of body mass) over 3 days preceding T4 injection.

Microarray study of gene expression in uterine leiomyoma.

Unlabelled: Uterine leiomyoma is a most common benign neoplasm in women of reproductive age. It arises from the myometrial compartment of the uterus and may transform in some cases to a malignant phenotype.

Aim: To identify the genes involved in pathogenesis of uterine leiomyoma.

Interleukin-6 -174G/C polymorphism in breast cancer and uterine leiomyoma patients: a population-based case control study.

Unlabelled: A common G/C polymorphism at position -174 of the interleukin-6 (IL-6) gene promoter is thought to affect the expression level of this gene, thus predisposing to a variety of diseases, including tumorigenesis.

Aim: To investigate the association of the -174 G/C IL-6 polymorphism with breast cancer and uterine leiomyoma in Ukrainian population.

Methods: We genotyped the -174 G/C IL-6 polymorphism in a group of healthy Ukrainians by pyrosequencing and compared the results to those previously published for other Caucasian populations.