[The use of the Siggaard-Andersen model of the oxyhemoglobin dissociation curve in patients in the immediate period following open heart surgery].

A total of 300 patients have been examined on the first-third day after surgical correction of acquired heart valve defects, aortocoronary bypass surgery, and left ventricular postinfarction aneurysm resection performed using cardiopulmonary bypass technique. The parameters of the cardio-respiratory system and the value of parameter a in Siggaard-Andersen oxyhemoglobin dissociation curve (ODC) model have been studied. It has been shown that in some patients (about 5%) arterial blood hemoglobin saturation with O2 was lower than the corresponding blood pO2.

[Hemoglobin-oxygen affinity in acute respiratory and circulatory disorders in patients following open heart surgery].

Hemodynamic parameters, lung gas exchange, hemoglobin, acid-base balance, gases, blood lactate and pO2 have been studied in 105 patients with acute cardiorespiratory disturbances (CRD) after open heart surgery. The actual P50 was determined by the venous point, using the Severinghaus blood gas analyser. The method of multidimensional regression analysis was used to study the contribution of some factors determining oxyhemoglobin dissociation curve (ODC) shift.

[The 2,3-diphosphoglycerate content and its influence on hemoglobin-oxygen affinity in patients following open heart surgery].

70 patients have been examined in the early postoperative period after aortocoronary bypass surgery and surgical correction of acquired heart valve defects. 2,3-diphosphoglycerate (DPG) concentration was shown to increase in acute postoperative disturbances. The increase was most pronounced in reduced oxygen transport to tissues.

[The Bohr effect during an uncomplicated course of the early postoperative period in heart surgery patients].

48 patients have been examined in the early postoperative period after open heart surgery (25 patients after correction of acquired heart valve defects and 23 patients after aortocoronary bypass surgery on 2-6 coronary arteries). Gas exchange parameters, hemodynamics, hemoglobin, gases, acid-base balance were studied and P50 was determined with the Severinghaus blood gas analyzer. Using a multidimensional regression analysis, the regularities of P50 changes in uncomplicated postoperative period have been investigated (namely coefficients of temperature and Bohr's shifts of oxyhemoglobin dissociation curve have been studied).