Publications by authors named "V N Thijs"
Background And Objectives: Data from randomized trials on the treatment effect of pure thrombolysis in patients with vessel occlusion are lacking. We examined data from a corresponding subsample of patients from the multicenter, randomized, placebo-controlled WAKE-UP trial to determine whether MRI-guided IV thrombolysis with alteplase in unknown-onset ischemic stroke benefits patients presenting with vessel occlusion.
Methods: Patients with an acute ischemic lesion visible on MRI diffusion-weighted imaging but no marked parenchymal hyperintensity on fluid-attenuated inversion recovery images were randomized to treatment with IV alteplase or placebo.
Article Synopsis
- The ETERNAL-LVO trial examines the effectiveness and safety of tenecteplase for patients with large vessel occlusion (LVO) within 24 hours of stroke onset, compared to standard care.
- The study is a randomized phase 3 trial involving patients with anterior circulation LVO and target mismatch on imaging, focusing on those who may need endovascular treatment.
- Key outcomes include measuring disability at 3 months using the modified Rankin Scale, alongside safety assessments like the incidence of symptomatic intracerebral hemorrhage and overall mortality.
Article Synopsis
- Blood-brain barrier disruption in acute ischemic stroke is linked to complications, with GLOS indicating issues in the blood-ocular barrier.
- In a study of WAKE-UP trial patients, 29% showed GLOS, significantly more than the 7% with HARM.
- GLOS presence was associated with factors like age, renal function, and white matter hyperintensity but did not correlate with hemorrhagic transformation or functional outcomes.
Article Synopsis
- Cerebral small vessel disease (SVD) can lead to various cerebrovascular issues, but research on sex differences in SVD is limited.
- This study analyzed data from over 20,000 patients with acute ischemic stroke to examine whether the presence and severity of cerebral microbleeds (CMB) and other SVD markers differ between males and females.
- Results showed that males had more frequent CMB while females had fewer lacunes but higher severe white matter hyperintensities, indicating distinct SVD characteristics based on sex.
Introduction: Large genome-wide association studies (GWASs) using case-control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a case-only design to identify loci influencing the age at onset (AAO) of ischemic stroke.
Methods: Analyses were conducted in a discovery cohort of 10,857 ischemic stroke cases using a linear regression framework.