[Metabolic changes in the rat liver during emotional stress].

Emotional stress of rats is accompanied by essential alterations in glycolysis and tricarboxylic acid cycle in the liver. These alterations were observed over a few days after the termination of stressor action. Perhaps it is one of the trigger mechanisms responsible for pathological changes in the organism.

[Biochemical characteristics of various adaptation mechanisms in acute alcoholic intoxication].

Phase character of metabolic shifts (ethanol, acetaldehyde, catecholamines content, alcohol dehydrogenase and aldehyde dehydrogenase activity) has been revealed in the experiments on white non-inbred rats after a single administration of a sub-narcotic dose of ethanol. Some adaptation-adjustment mechanisms have been established which promote the decrease of the toxic effect of alcohol (induction of activity of alcohol-metabolising enzymes and condensation of acetaldehyde with catecholamines).

[The role of acetaldehyde in the pathogenetic mechanisms of the development of chronic alcoholism].

Experiments on white rats were carried out to confirm an important role of acetaldehyde in pathogeny of alcoholism. It is evidenced by results of experiments when animals were given acetaldehyde and medichronal (a drug which combines acetaldehyde) and by data obtained in the course of studies of changes in the content of endogenic ethanol and acetaldehyde, activity of alcohol dehydrogenase and aldehyde dehydrogenase, concentration of biogenic amines (catecholamines and serotonin) in the blood and brain structures.

[Norepinephrine content in various brain structures and activity of alcohol dehydrogenase and aldehyde dehydrogenase in blood serum of rats with varying predisposition to ethanol consumption].

Noradrenaline content in hypothalamus, midbrain and new cortex as well as the activity of alcohol- and aldehyde dehydrogenase in the blood serum of rats with different alcohol motivation were studied. It is shown that rats, which prefer ethanol, are characterized by the lower content of noradrenaline in hypothalamus, midbrain and new cortex as compared to animals which prefer water. It is found out that alcohol motivation in rats correlates with high activity of blood serum aldehyde dehydrogenase.