Supernatants from Newly Isolated P4 Ameliorate Adipocyte Metabolism in Differentiated 3T3-L1 Cells.

() strains and their postbiotics show potential for managing metabolic disorders such as diabetes and obesity. Two newly isolated strains, M2.1 and P4, were yielded from anthills in Sinite Kamani National Park, Bulgaria.

Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single-Gene BDH1 Duplications.

Background: Chromosome 3q29 duplication syndrome is a rare chromosomal disorder with a frequency of 1:5000 in patients with a neurodevelopmental phenotype. The syndrome is characterized by phenotypic polymorphism and reduced penetrance.

Methods: Patients were investigated by performing a cytogenetic analysis of GTG-banded metaphases, aCGH with the SurePrint G3 Human CGH Microarray 8×60K, qPCR, FISH, and WES.

Development of a Sealed Rechargeable Li-SO Battery.

Rechargeable Li-SO batteries offer low-cost, high-energy density benefits and can leverage manufacturing processes for the existing primary version at a commercial scale. However, they have so far only been demonstrated in an "open-system" with continuous gas supply, preventing practical application. Here, the utilization and reversibility of SO along with the lithium stability are addressed, all essential for long-life, high-energy batteries.

Mucoadhesive polyelectrolyte complexes of fucoidan and chitin nanowhiskers to prolong the antiprotozoal activity of metronidazole.

The improvement of the specific pharmacological activity of agents with antimicrobial and antiprotozoal properties (e.g. metronidazole, MET) is of interest for clinical applications in the treatment of bacterial infections.

Delivery system for dexamethasone phosphate based on a Zn-crosslinked polyelectrolyte complex of diethylaminoethyl chitosan and chondroitin sulfate.

Hybrid nano- and microparticles based on metal ion crosslinked biopolymers are promising carriers for the development of drug delivery systems with improved biopharmaceutical properties. In this work, dexamethasone phosphate-containing particles based on chondroitin sulfate and chitosan or diethylaminoethyl chitosan additionally crosslinked with Zn were prepared. Depending on the polycation/polyanion ratio in the system, anionic and cationic polyelectrolyte complexes (PECs) were obtained.