[Immunotropic activity of new hydroxypyrimidine derivatives].

The studies on immunotropic activity of the new hydroxypyrimidine derivative, 2,4,6-trimethyl-5-oxypyrimidine, have shown the compound to exert a predominant suppressant action on cell-mediated immune reactions without inhibiting antibody formation. After single intraperitoneal administration at doses within 50-500 mg/kg the drug produces a marked lymphotoxic action (27-46% of survived colony-forming cells), with the mitostatic effect being absent. No direct correlation between the drug dose and its action was recorded: an increase in the dose up to 500 mg/kg does not induce the effect potentiation.

[Dynamics of the change in cyclic nucleotide content in wound tissues].

Changes in the content of cyclic nucleotides (cAMP and cGMP) in the wound tissues (muscles and granulations) were studied in experiments on rats. A wound with skin defect in the dorsal area with a crushed underlying muscle served as an experimental model. It was shown that the cAMP content in the muscular tissue rises twice: during the 1st day and to a greater measure on the 7th day.