Publications by authors named "V N Levchenko"
In 2012, bicyclo[1.1.1]pentanes were demonstrated to be bioisosteres of the benzene ring.
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- - The study highlights the important function of the K5.1 potassium channel (KCNJ16) in regulating electrolyte balance and blood pressure, with previous research showing its mutations can lead to health issues like hypokalemia and renal problems.
- - Researchers discovered a new variant, I26T, in an Amish patient, who experienced symptoms like polydipsia and metabolic acidosis, and then developed an animal model to better understand this mutation.
- - Findings from the rat model showed that the I26T variant did not significantly affect blood pressure, electrolyte levels, or renal function compared to normal rats, suggesting it may be a benign mutation rather than a harmful one.
Maintaining acid-base homeostasis is critical for normal physiological function. The kidneys are essential for regulating acid-base homeostasis through maintaining systemic bicarbonate concentration. Chronic metabolic acidosis is an independent risk factor for chronic kidney diseases.
View Article and Find Full Text PDFThe inwardly rectifying K channel K5.1 () is essential in renal salt handling and blood pressure control. However, the underlying mechanisms are not fully understood.
View Article and Find Full Text PDFZinc is one of the essential divalent cations in the human body and a fundamental microelement involved in the regulation of many cellular and subcellular functions. Experimental studies reported that zinc deficiency is associated with renal damage and could increase blood pressure. It was proposed that zinc dietary supplementation plays a renoprotective role.
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