[Increased sensitivity to drugs and endometriosis].

Increasing incidence of predominantly polyvalent drug allergy was demonstrated in patients with endometriosis as an obstacle to their purposive treatment. For this reason, a system of measures aiming to prevent allergic and pseudoallergic reactions has been developed with respect to pathogenetic mechanisms involved, to be used in conjunction with conservative treatment, general anesthesia for surgical interventions and roentgenocontrast investigation in patients with endometriosis and polyvalent hypersensitivity to medication.

[In vitro diagnosis of penicillin and streptomycin allergy. The specific leukocyte alteration reaction using luminescence microscopy].

The method of fluorescent microscopy was used for studying the diagnostic value of the reaction of the leucocyte specific alteration (LSA) in patients with different syndromes of hypersensitivity, allergy in the anamnesis and without hypersensitivity to penicillin and streptomycin. It was found that only markedly positive results of the LSA reaction (independent of the sensibilization type) were of diagnostic value, the results of the reaction being stated in half of the patient with hypersensitivity in the anamnesis and in 3/5 of the patients with allergy. Simultaneous use of other tube immunological or skin tests was recommended for the other patients with lower levels of the positive results of the LSA reaction with a purpose of etiological diagnostics or revealing latent sensibilization before treatment with the antibiotics.