Publications by authors named "V N Kolpakov"
A large number of cattle breeds have marked phenotypic differences. They are valuable models for studying genome evolution. ROH analysis can facilitate the discovery of genomic regions that may explain phenotypic differences between breeds affecting traits of economic importance.
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- Modern microtechnology enables the creation of chip-based neural networks with modular and hierarchical structures that mimic brain networks, providing a model for studying interactions and functionality.
- A two-chamber microfluidic platform was utilized to assess functional connectivity and overall activity within these hierarchical modular neural networks.
- Results indicated that both the strength of connections within modules and the nature of spontaneous activity influence how effectively modules interact and integrate, potentially leading to insights into function-structure relationships in neural networks in various health conditions.
Despite the unconditional success achieved in the treatment and prevention of AMI over the past 40 years, mortality in this disease remains high. Hence, it is necessary to develop novel drugs with mechanism of action different from those currently used in clinical practices. Studying the molecular mechanisms involved in the cardioprotective effect of adapting to cold could contribute to the development of drugs that increase cardiac tolerance to the impact of ischemia/reperfusion.
View Article and Find Full Text PDFThe role of β-adrenergic receptors in the regulation of cardiac tolerance to ischemia/reperfusion. Why do β-adrenergic receptor agonists and antagonists protect the heart?
Fundam Clin Pharmacol
August 2024
Background: Catecholamines and β-adrenergic receptors (β-ARs) play an important role in the regulation of cardiac tolerance to the impact of ischemia and reperfusion. This systematic review analyzed the molecular mechanisms of the cardioprotective activity of β-AR ligands.
Methods: We performed an electronic search of topical articles using PubMed databases from 1966 to 2023.
Prevalence of Promoter Mutations in Orbital Solitary Fibrous Tumors.
Curr Issues Mol Biol
February 2024
The orbital manifestation of a solitary fibrous tumor (SFT) is exceptionally rare and poses specific challenges in diagnosis and treatment. Its rather exceptional behavior among all SFTs comprises a high tendency towards local recurrence, but it rarely culminates in metastatic disease. This raises the question of prognostic factors in orbital SFTs (oSFTs).
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