The reconstruction of evolutionary dynamics of processed pseudogenes indicates deep silencing of "retrobiome" in naked mole rat.

Approximately half of mammalian genomes are occupied by retrotransposons, highly repetitive interspersed genetic elements expanded through the mechanism of reverse transcription. The evolution of this "retrobiome" involved a series of explosive amplifications, presumably associated with high mutation rates, interspersed with periods of silencing. A by-product of retrotransposon activity is the formation of processed pseudogenes (PPGs)-intron-less, promoter-less DNA copies of messenger RNA (mRNA).

Synthesis of Higher Alcohols from Syngas over a K-Modified CoMoS Catalyst Supported on Novel Powder and Fiber Commercial Activated Carbons.

In the present study, a series of K-modified CoMoS catalysts with compositions of 10% K, 3.6% Co, and 12 wt % Mo supported over novel commercial activated carbons such as powder materials (DAC and OBC-1) and fiber materials (fabric active sorption (TCA) and nonwoven activated material (AHM)) were prepared and characterized by Brunauer-Emmett-Teller (BET), X-ray fluorescence (XRF), scanning electron microscopy (SEM), SEM-energy dispersive X-ray (EDX), and transmission electron microscopy (TEM). The catalytic activities for higher alcohol synthesis from syngas, conducted at = 300-360 °C, = 5 MPa, GHSV = 760 L h (kg cat), and H/CO = 1.

Eros, Beauty, and Phon-Aesthetic Judgements of Language Sound. We Like It Flat and Fast, but Not Melodious. Comparing Phonetic and Acoustic Features of 16 European Languages.

This article concerns sound aesthetic preferences for European foreign languages. We investigated the phonetic-acoustic dimension of the linguistic aesthetic pleasure to describe the "music" found in European languages. The Romance languages, French, Italian, and Spanish, take a lead when people talk about melodious language - the music-like effects in the language (a.

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.

Adipose tissue is recognized as a major source of systemic inflammation with age, driving age-related tissue dysfunction and pathogenesis. Macrophages (Mφ) are central to these changes yet adipose tissue Mφ (ATMs) from aged mice remain poorly characterized. To identify biomarkers underlying changes in aged adipose tissue, we performed an unbiased RNA-seq analysis of ATMs from young (8-week-old) and healthy aged (80-week-old) mice.

Cytotoxicity of Exogenous Acetoacetate in Lithium Salt Form Is Mediated by Lithium and Not Acetoacetate.

Background/aim: The ketogenic diet has recently gained interest as potential adjuvant therapy for cancer. Many researchers have endeavored to support this claim in vitro. One common model utilizes treatment with exogenous acetoacetate in lithium salt form (LiAcAc).