Publications by authors named "V N Jacobs"
Fluorescence imaging has been widely used in fields like (pre)clinical imaging and other domains. With advancements in imaging technology and new fluorescent labels, fluorescence lifetime imaging is gradually gaining recognition. Our research department is developing the CAM, based on the Current-Assisted Photonic Sampler, to achieve real-time fluorescence lifetime imaging in the NIR (700-900 nm) region.
View Article and Find Full Text PDFMerkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a poor prognosis. One of the major mechanisms of immune evasion in MCC involves downregulation of major histocompatibility complex class I (MHC-I). Anti-PD-1/programmed death ligand 1 checkpoint inhibitors have revolutionized treatment for MCC, producing objective responses in approximately 50% of patients, and are now the standard of care; however, a substantial proportion of patients either fail to respond or develop resistance to checkpoint inhibitors.
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- Pancreatic adenocarcinoma (PDAC) is a challenging cancer to treat with immunotherapies, but certain intratumoral structures called tertiary lymphoid structures (TLS) have been linked to better patient survival outcomes.
- A comprehensive study analyzed 26 PDAC tumors using advanced techniques like machine learning and spatial transcriptomics to better understand the role of TLS within tumors.
- The findings revealed specific gene expression patterns in TLS that correlate with improved survival, highlighting the importance of TLS maturation and its interactions with immune cells and the tumor environment.
In conversation, recognizing social actions (similar to 'speech acts') early is important to quickly understand the speaker's intended message and to provide a fast response. Fast turns are typical for fundamental social actions like questions, since a long gap can indicate a dispreferred response. In multimodal face-to-face interaction, visual signals may contribute to this fast dynamic.
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- - Atrial fibrillation (AF) increases the risk of cognitive decline and dementia, especially in patients with a history of stroke; anticoagulation strategies can influence long-term dementia risk in AF patients.
- - The CAF Trial examined the effects of dabigatran and warfarin on cognitive health in patients with non-valvular AF and found no significant changes in cognitive function or dementia occurrence over 24 months.
- - Both dabigatran and well-managed warfarin therapy showed similar outcomes regarding stroke, cognitive decline, and dementia within two years, leading to the conclusion that either anticoagulation strategy is viable without the need for a larger study.