[The phenomenon of pseudotumorous cross immunohistochemical reactivity of glia in progressive multifocal leukoencephalopathy].

Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating brain damage caused by infection of oligodendrocytes and astrocytes with the lytic JC virus on the background of immunosuppression. A case report of PML with a tumor-like course is presented. Morphological diagnostics revealed non-specific staining of antibodies to Ki-67, p53, IDH1, NF and Vim in the nuclei of gliocytes affected by the JC virus.

Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus.

The model of streptozotocin-induced diabetes mellitus in C57Bl/6 mice was employed to study the role of precursors of insulin-producing β-cells, hematopoietic stem cells, and progenitor hematopoietic cells in inflammation. In addition to provoking hyperglycemia, streptozotocin elevated serum levels of IL-1β and hyaluronic acid, induced edema in the pancreatic insular tissue and its infiltration by inflammatory cells (neutrophils, lymphocytes, and macrophages) and fibroblasts. Inflammation in pancreatic islets was accompanied by necrotic processes and decreasing counts of multipotent progenitor β-cells (CD45(-), TER119(-), c-kit-1(-), and Flk-1(-)), oligopotent progenitor β-cells (CD45(-), TER119(-), CD133(+), and CD49f(low)), and insulinproducing β-cells (Pdx1(+)).

[A rare case of small-cell diffuse invasive breast lobular carcinoma].

The paper describes a rare case of invasive lobular carcinoma with the diffuse growth type simulating malignant non-Hodgkin lymphoma. The immunohistochemical study of the tumor established a marked expression of pancytokeratin, GSDFP-15, receptors to estrogen and progesterone, CD 7, Bcl-2, expression CD 3, CD 5, CD 10, CD 20, CD 23, CD 30, ALK, Bcl-6, inactive expression of E-cadherin. The ability of invasive lobular carcinoma to simulate malignant non-Hodgkin lymphoma determines the diagnostic value and significance of an immunohistochemical study to confirm the epithelial nature of the tumor.

[Immunohistochemical study in the diagnosis of tuberculosis].

The comparative analysis of the immunohistochemical method and Ziehl-Neelsen staining was used to search for a new highly sensitivity procedure for diagnosing tuberculosis. With both methods, mycobacteria tuberculosis were detected in 10 cases of fibrocavernous pulmonary tuberculosis, 1 case of general tuberculosis, and 10 cases of disseminated lung lesion (sarcoidosis?). The improved immunohistochemical option using Mycobacterium tuberculosis antibodies (clone 1.

[Natural killer cells (CD56, CD16) as a factor of local antitumor immunity in breast cancer].

Two groups of malignancies with significantly distinct ratios of Ki-67 and CD16 expression were identified. Significant direct and inverse correlations between the markers were established (p < 0.01) whereas either group revealed two contradicting patterns of immune response.