Effect of blood lipoproteins and apolipoproteins A-I, C, and E on the microviscosity of erythrocyte membranes.

We studied in vitro modifying effect of high-density lipoproteins, low-density lipoproteins, very-low-density lipoproteins, and apolipoproteins A-I, C, and E on membrane structure of rat erythrocytes. Incubation of erythrocyte membranes with lipoproteins was accompanied by significant changes in the behavior of fluorescent probe pyrene in the hydrophobic membrane region. The regulatory effect of lipoproteins was probably realized via exchange of lipid components between these particles and erythrocyte membrane.