[Biochemical and ultrastructural changes in the periodontium during the chronic administration of pro-oxidant xenobiotics].

Effects of chronic administration of xenobiotics pro-oxidants on the state of periodontal tissues, level of free-radical oxidation of lipids, and antioxidant provision were studied. Diphenin and delagil were found to promote biochemical and morphological changes similar to the manifestations observed in periodontitis. A conclusion is made about an important role of nonenzymatic free-radical oxidation of lipids and biopolymers in the pathogenesis of periodontitis.

[Experimental and clinical bases for the use of antioxidants as agents for treating and preventing periodontitis].

The contribution of free-radical lipid and biopolymer oxidation to the pathogenesis of periodontitis is analyzed as reflected in published Russian and foreign literature. Enhanced autooxidation in periodontal tissue is shown to represent one of the mechanisms of the disease genesis, this prompting the use of antioxidants in the treatment an prophylaxis of periodontitis. Antioxidant effects on the course of the disease have been demonstrated experimentally and clinically.

[Free radical processes in the pathogenesis of alloxan diabetes].

Presents the results of studies of carbohydrate and peroxide metabolism, of antioxidant content in rats with alloxan diabetes under various levels of alimentary antioxidant consumption. Alloxan administration was found to result in biochemical and morphologic shifts characteristic of diabetes mellitus. The development of these changes runs against the background of enhanced free-radical processes.