[Coupling of calcium homeostasis and lipid peroxidation in mechanisms of bronchial hyperreactivity in patients with bronchial asthma].

A comparative study of calcium homeostasis, calcium regulating system and lipid peroxidation has been done with 16 bronchial asthma patients (BA) at bronchospasm of physical effort (BPhE) and with 15 asthma attack patients in remission period. The data obtained point to the close pathogenetic link between the changes of calcium homeostasis, hormonal calcium regulating system and LPO strengthening the appearance of hyperreactivity of bronchial tree and BA.

[The pathochemical mechanisms of bronchospasm after physical exertion in bronchial asthma patients].

As many as 71 bronchial asthma (BA) patients and 12 patients suffering from chronic asthmatic bronchitis were examined in the stage of subsiding exacerbation. Before and 10 minutes after exercise measurements were made of the blood content of histamine (H), PGF2 alpha and PGE, adrenaline (A) and noradrenaline (NA), hydroperoxides (HP), and of the general and non-protein thiol groups. The initial level of H, PGF2 alpha, HP, A and NA was so much higher than the control value and the degree of its increase after exercise was so much more significant the more pronounced bronchospasm of effort (BE).

[The effect of a single dose of nifedipine, intal, sodium thiosulfate and Essentiale on the blood level of calcium, hydroperoxides, thiol compounds and prostaglandins in bronchial asthma patients].

A study was made of the impact of a single intake of nifedipine, intal, sodium thiosulfate and essentiale on respiratory function, the blood content of ionized calcium, total calcium, hydroperoxides, total and non-protein thiol groups, and prostaglandins in bronchial asthma patients. All the drugs exerted an antioxidant action, which is supported by the lowering of the content of hydroperoxides after their administration and by an increase of the content of thiol groups. A rise of the level of PGE and a considerable reduction of blood serum PGF2 alpha, most remarkable after essentiale administration were also noted.

[The interconnection of changes in the level of prostaglandins, catecholamines, and lipid peroxidation of membrane lipids in patients with bronchial asthma].

Dynamics of alterations in content of prostaglandins (PG) F2 alpha and E and in the ratio PGF2 alpha/PGE was studied in blood plasma of 24 patients with chronic asthmatic bronchitis and 109 patients with bronchial asthma. Alterations in content of PGF2 alpha correlated with severity of the disease, while PGE content was similarly below the control values in all the groups examined. The ratio PGF2 alpha/PGE corresponded with the alterations in content of PGF2 alpha.

[Relationship of the changes in catecholamines, thiol compounds, and lipid peroxidation in bronchial asthma].

Dynamics of adrenaline (A), noradrenaline, SH-groups and lipid peroxidation (LP) was studied in 34 patients with chronic asthmatic bronchitis and in 132 patients with bronchial asthma. The data obtained suggest that ratios A.10/LP and SOD/SH.