METHODOLOGY OF RECONSTRUCTION OF INTERNAL DOSES FROM 137Cs AND 134Cs OF RESIDENTS OF RADIOACTIVELY CONTAMINATED SETTLEMENTS IN UKRAINE NOT COVERED BY WBC MONITORING.

Objective: Scientific justification of the methodology for calculating radiation internal doses from 137Cs and 134Cs intake for residents of Ukrainian settlements radioactively contaminated as a result of the Chornobyl (Chernobyl) accident in which measurements of incorporated radiocesium isotopes in humans using whole-body counters (WBC) were not carried out.

Materials And Methods: The paper presents a new methodology for reconstructing doses due to internal irradiation from Chornobyl fallout for both surface (in 1986) and root (in 1987-2023) contamination of vegetation with 137Cs and 134Cs and their transfer into the human body. The methodology for calculating the dose due to surface contamination of vegetation was based on the theoretical model of the transfer of radiocesium isotopes through the food chain with further adjustment of this model to the results of WBC measurements carried out between 15 July and 31 December 1986.

STUDY OF DOSE FORMATION FOR THE POPULATION IN RADIOACTIVELY CONTAMINATED AREAS OF ZHYTOMYR REGION BASED ON COMPREHENSIVE RADIATION-HYGIENIC MONITORING.

Objective: the research is to determine the main radiation-hygienic factors influencing the formation of radiation doses among the population of radioactively contaminated territories (RCT) in Zhytomyr region in 2024 and to analyze the dynamics of internal radiation doses based on original experimental studies conducted in reference settlements from 2012 to 2024.

Materials And Methods: In 2024, a comprehensive radiation-hygienic monitoring program was conducted in 11 settlements of Narodychi Territorial Community (TC): the Narodychi and the villages of Selets, Bazar, Rudnya Bazarska, Khrystynivka (Zone 2), Motiyki, Zalissya, Davydky, Radcha, Nova Radcha, and Grezlya (Zone 3). The comprehensive radiation-hygienic monitoring included the following activities: mobile WBC monitoring: 817 measurements (562 adults and 255 children); collection and analysis of food samples: 39 milk samples, 61 potato samples, and 57 samples of wild foods, analyzed for radionuclide content, including 137Cs and 90Sr; assessment of external radiation exposure in these settlements; surveys: 194 individuals were surveyed regarding the consumption volumes of locally produced foods from their own households and purchased foods from commercial networks.

Changes in Expression of Key Genes in Ceca of Chicken Broilers as Affected by Glyphosate, Antibiotics and a Coccidiostat.

Studies have shown the presence of residual amounts of the herbicide glyphosate in poultry feed, which leads to its bioaccumulation in the body. Recently, it has been established that exposure to low levels of glyphosate over a long period may have serious negative effects on poultry health. Moreover, combined exposure to several toxicants can potentially lead to additive and/or synergistic effects.

Bulevirtide Monotherapy Is Safe and Well Tolerated in Chronic Hepatitis Delta: An Integrated Safety Analysis of Bulevirtide Clinical Trials at Week 48.

Background And Aims: The safety and tolerability of bulevirtide (BLV), a novel entry inhibitor of hepatitis delta virus, were evaluated in an integrated analysis of clinical trial results from patients with chronic hepatitis delta (CHD).

Methods: Week 48 on-treatment clinical and laboratory results from two Phase 2 trials (MYR203 [NCT02888106] and MYR204 [NCT03852433]) and one Phase 3 trial (MYR301 [NCT03852719]) were pooled (N = 269). Patients were grouped as follows: BLV 2 mg (n = 64), BLV 10 mg (n = 115), pegylated interferon-alfa (n = 39) and control (n = 51).

Functional 20S Proteasomes in Retroviruses: Evidence in Favor.

Proteasomes are barrel-like cellular protein complexes responsible for the degradation of most intracellular proteins. Earlier, it has been shown that during assembly, hundreds of different cellular proteins are incorporated into retro-and herpes viruses. Among detected cellular proteins, there were different proteasome subunits (PS).