ACEGEN: Reinforcement Learning of Generative Chemical Agents for Drug Discovery.

In recent years, reinforcement learning (RL) has emerged as a valuable tool in drug design, offering the potential to propose and optimize molecules with desired properties. However, striking a balance between capabilities, flexibility, reliability, and efficiency remains challenging due to the complexity of advanced RL algorithms and the significant reliance on specialized code. In this work, we introduce ACEGEN, a comprehensive and streamlined toolkit tailored for generative drug design, built using TorchRL, a modern RL library that offers thoroughly tested reusable components.

Learning and forgetting using reinforced Bayesian change detection.

Agents living in volatile environments must be able to detect changes in contingencies while refraining to adapt to unexpected events that are caused by noise. In Reinforcement Learning (RL) frameworks, this requires learning rates that adapt to past reliability of the model. The observation that behavioural flexibility in animals tends to decrease following prolonged training in stable environment provides experimental evidence for such adaptive learning rates.

Opportunistic screening for Chlamydia at a community based contraceptive service for young people.

Problem: The suspected high prevalence of Chlamydia infection that is undiagnosed and untreated among high risk women who attend a contraceptive service for young people.

Design: Cross sectional study from a community screening service.

Background And Setting: An inner city contraceptive and psychotherapy service for young people aged 12-21 years.

[Monitoring of the oxygen saturation of horses during halothane anesthesia using pulse oximetry in the nasal septum].

The use of pulse oximetry for on-line monitoring of oxygen saturation of arterial blood using a probe on the nasal septum is described in the horse. When compared to the results of blood gas analysis an excellent correlation between the two methods for measuring oxygen saturation is found. Nevertheless a discrepancy between the values for oxygen saturation provided by either method is found.