Publications by authors named "V Millischer"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
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- The study investigates the link between the gut microbiome and schizophrenia spectrum disorders (SSD), analyzing feces from 52 young adult SSD patients and 52 controls using advanced sequencing techniques.
- Results showed that SSD patients had lower α-diversity and distinct β-diversity in their gut bacteria compared to controls, highlighting significant differences in both bacterial species and gene functions.
- Machine learning classifiers effectively distinguished SSD patients from healthy individuals based on their gut microbiome data, indicating potential biomarkers and further supporting the idea of microbiome alterations in SSD.
Article Synopsis
- * Researchers examined 4,925 immune-related genes and their association with lithium treatment response and clinical features in a large bipolar patient sample.
- * Findings indicate a few genetic associations with treatment response and clinical characteristics, revealing potential biomarkers, but overall support a weak connection between immune factors and bipolar disorder at a genetic level.