Publications by authors named "V Michelle Silvera"

Article Synopsis
  • Spontaneous intracranial hypotension is primarily caused by spinal CSF leaks, mostly reported in adults, but this report focuses on its occurrence in children.
  • Recent advances in specialized myelography techniques have improved the localization of these leaks, yet there's been limited research in the pediatric population due to the rarity of the condition and concerns about invasive procedures.
  • This study reviews pediatric cases with spontaneously occurring spinal CSF leaks, identifying similar leak types found in adults, and demonstrates that advanced imaging techniques can effectively pinpoint and aid in the treatment of these leaks.
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Article Synopsis
  • Inflammatory bowel diseases (IBDs), like Crohn's disease and ulcerative colitis, are chronic conditions affecting the digestive tract, particularly in children.
  • First-line treatments include anti-TNFα antibodies, such as infliximab and adalimumab, but about 30% of patients may not respond initially or can lose their response later on.
  • New therapeutic strategies, including small molecule drugs and combination therapies, are being explored, but data on their safety and effectiveness in pediatric IBD remains limited.
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Most primary orbital pathology in children is due to bacterial infection. Radiologists typically encounter these cases to evaluate for clinically suspected postseptal orbital involvement. Contrast-enhanced cross-sectional imaging is important for the detection and early management of orbital infection and associated subperiosteal/orbital abscess, venous thrombosis, and intracranial spread of infection.

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Pituitary development arises from ectodermal tissue creating Rathke's pouch and ultimately the adenohypophysis anteriorly whereas neuroectodermal tissue arising from the diencephalon creates the neurohypophysis posteriorly. Alterations in pituitary development can lead to hormonal dysregulation and dysfunction. Following clinical suspicion of pituitary endocrinopathy, MRI plays a vital role in identifying and characterizing underlying structural abnormalities of the pituitary gland, as well as any associated extrapituitary findings.

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Importance: Physical abuse is a common but preventable cause of long-term childhood morbidity and mortality. Despite the strong association between abuse in an index child and abuse in contact children, there is no guidance outlining how to screen the latter, significantly more vulnerable group, for abusive injuries. Consequently, the radiological assessment of contact children is often omitted, or variably performed, allowing occult injuries to go undetected and increasing the risk of further abuse.

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