Publications by authors named "V Metelskaya"
Background/objectives: Recent data indicate the involvement of skeletal muscles in the regulation of metabolism and in the pathogenesis of chronic noncommunicable diseases. The goal of our study was to describe the serum concentrations of myokines in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertension (HTN) and their correlation with laboratory parameters, blood pressure (BP), and MASLD severity.
Methods: A total of 67 patients with MASLD and HTN underwent anthropometric measurements, laboratory tests, and point shear-wave elastography.
Objective: To evaluate the associations between analytical methods, such as microarray and enzyme-linked immunosorbent assay (ELISA); expedient cutoffs; and the lowest possible number of microarrays in analysis for target biomarker estimation in case-control studies.
Methods: This study included 321 serum specimens, gathered in different case-control studies to test for atherosclerosis and atrial fibrillation. Among them, 48 serum specimens were analyzed using microarray technology.
Article Synopsis
- The study investigates the link between adenovirus-specific antibodies (AdV-IgG) and atrial fibrillation (AF), suggesting that adenoviral infection might contribute to the development of AF.
- Two groups of patients were analyzed: those with AF (group MA) and asymptomatic individuals (group MB), with results indicating higher adenovirus signals in AF patients.
- AdV-IgG positivity was found to be twice as common in AF patients compared to controls, and there was a significant association between obesity and AdV-IgG positivity among AF patients, indicating a potential connection between adenoviral infection, AF, and body weight.
Article Synopsis
- The study investigated the relationship between routine and experimental biomarkers and the risk of cardiovascular death and acute myocardial infarction (AMI) using data from a multicenter study in Russia.
- Elevated levels of cardiac troponin I (cTnI), C-reactive protein (CRP), and nitric oxide metabolites (NOx) were linked to higher risks of cardiovascular death and nonfatal AMI, while angiopoietin-like protein 3 (ANGPTL3) indicated a lower risk for cardiovascular death but higher for nonfatal AMI.
- The findings suggest further research is needed to validate the predictive value of these biomarkers to improve patient risk assessment in cardiovascular health.
Protein expression profiling in the serum is used to identify novel biomarkers and investigate the signaling pathways in various diseases. The aim of the present study was to evaluate serum biomarkers associated with coronary artery stenosis resulting from atherosclerosis. The study included 4 groups of subjects: group A and B with and without coronary lesions, respectively, were selected from a previously reported cohort study on coronary atherosclerosis, control group C comprised of asymptomatic subjects and group D was used for independent validation of the microarray data by ELISA.
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