IMMUNOLOGICAL DISTRESS IN EXPERIMENTAL CRANIAL TRAUMA COMBINED WITH INSULIN DEPENDENT DIABETES (EXPERIMENTAL STUDY).

This article describes the immunological events and investigates important mediators of the inflammatory immune response after experimental cranial trauma combined with type I diabetes. It was shown that the rats with induced diabetes and traumatic brain injury suffered more profound damage to the immune system that was not restored back to the basal level within 14 days. Proinflammatory cytokine concentrations increased, while anti-inflammatory cytokine concentrations decreased by day 14, increasing risk for systemic inflammatory response syndrome and multi-organ failure.

[The dynamics of the immune status indices in conditions of cranio-cerebral trauma on background of a streptozotocin-induced diabetes mellitus in experiment].

Peculiarities of changes in the immune status in a cranio-cerebral trauma (CCT) on a background of a streptozotocin-induced diabetes mellitus (DM) were studied up. After CCT there are noted the inhibition of predominantly cellular link of immunity, accompanied by reduction of the CD3+ lymphocytes quantity, as well as lymphocytes of the main subpopulations CD4+ and CD8+, CD16+, reduction of the neutrophils phagocytic activity, a complement titer enhancement. Experimental CCT do not cause the essential changes in a CD19+ lymphocytes quantity.

[The humoral immunity changes in experimental cranio-cerebral trauma, concurrent with diabetes mellitus].

The results of studying in dynamics of the humoral immunity indices were adduced in experimental cranio-cerebral truma (CCT) in conjunction with diabetes mellitus (DM). Peculiarities of the immune answer while the period of an acute reaction on trauma and early signs of posttraumatic period have been characterized by reduction of content in the main classes of immunoglobulins IgA, IgM, IgG and enhancement of the circulating immune complexes (CIC) concentration. Experimental DM was accompanied by raising of functional activity of humoral immunity in accordance with immunoglobulins level and CIC.

[Morphological changes in internal organs of animals in different periods of craniocerebral trauma on background of diabetes mellitus].

Dystrophic, destructive and infiltrative processes, which have had formatted on background of significant hematological disorders, were observed in internal organs of rats while simulating isolated craniocerebral and craniocerebral trauma on background of diabetes mellitus. The most significant reactive changes were noted in parenchymatous components of these organs. In the rats in conditions of isolated craniocerebral trauma they were maximal on the first day of the investigation and had a stable positive dynamics on the fifth day.