Preclinical evaluation of transaxial intraputaminal trajectory for enhanced distribution of grafted cells in Parkinson's disease.

Objective: The objective of this study was to develop and evaluate the feasibility and safety of a novel transaxial surgical approach for the delivery of human induced pluripotent stem cell-derived dopaminergic neuroprogenitor cells (DANPCs) into the putamen nucleus using nonhuman primates and surgical techniques and tools relevant to human clinical translation.

Methods: Nine immunosuppressed, unlesioned adult cynomolgus macaques (4 females, 5 males) received intraputaminal injections of vehicle or DANPCs (0.9 × 105 to 1.

Quantification of early gait development: Expanding the application of Catwalk technology to an infant rhesus macaque model.

Background: Understanding gait development is essential for identifying motor impairments in neurodevelopmental disorders. Defining typical gait development in a rhesus macaque model is critical prior to characterizing abnormal gait. The goal of this study was to 1) explore the feasibility of using the Noldus Catwalk to assess gait in infant rhesus macaques and 2) provide preliminary normative data of gait development during the first month of life.

Cyclic Amp phosphodiesterase activity in normal and inflamed human dental pulp.

Cyclic AMP phosphodiesterase (cAMP PDE) seems to be important in pulp tissues. High levels of cAMP PDE have been demonstrated to be in dental pulp cells. In the present study cAMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis.

[Identification of macronutrients and some oligoelements in "molisano" Tuber aestivum truffles].

Many scientifical published works have documented the presence of macro and micronourished of truffle coming from Umbria, Toscana, and Piemonte, while are few the studies that documented the analysis of these nourishes of the truffle coming from Molise. In our study has been evaluated the concentrations of macro-nourishes and oligoelements in Molisano Tuber aestivum truffle. The contents of macro-nourishes (proteins, carbohydrates, lipids, and water) and oligoelements (lead, cadmium, chromium, manganese, zinc, nickel, and copper) have been determined.

Food-intake and nutrients pattern in Italian adult male subjects.

Energy is necessary for all physiological functions of the body. Most of the vitamins are enzymes that require additional mineral as cofactors. Aim of the study was to evaluate the food intake and nutrients pattern in an adult population.