Publications by authors named "V Meneghini"
Article Synopsis
- Human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NSCs) show potential for treating neurodegenerative disorders, but studies on their safety and identity are limited.
- This research reveals that hiPSC-NSCs have a similar profile to human fetal neural stem cells and differ from glioblastoma stem cells, with successful long-term transplantation in mice without tumor formation.
- The study highlights the role of the SREBF1 gene in astroglial differentiation, providing important data to assess the maturation and safety of hiPSC-NSCs for future clinical uses.
Article Synopsis
- The study investigates the link between antithyroperoxidase antibodies (TPOAb) and carotid intima-media thickness (cIMT) to better understand how thyroid autoimmunity relates to cardiovascular disease.
- It analyzed data from 9,264 participants without prior cardiovascular issues, finding that varying levels of TPOAb were significantly associated with increased cIMT at the initial assessment.
- However, there was no significant connection between TPOAb levels and increased cIMT at the follow-up after eight years, particularly in individuals with normal thyroid function.
The association of thyroid function with essential and non-essential amino acids is understudied, despite their common metabolic roles. Thus, our aim was to evaluate the association of thyroid function with the levels of branched-chain amino acids (BCAAs-leucine, isoleucine, and valine) and of alanine in the general population. We utilized data from the São Paulo research center of ELSA-Brasil, a longitudinal population-based cohort study.
View Article and Find Full Text PDFAssociations of TSH, free T3, free T4, and conversion ratio with incident hypertension: results from the prospective Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Arch Endocrinol Metab
May 2024
Objective: To evaluate the association of TSH, free T3 (FT3), free T4 (FT4), and conversion (FT3:FT4) ratio values with incident hypertension.
Materials And Methods: The study included data from participants of the ELSA-Brasil study without baseline hypertension. Serum TSH, FT4 and FT3 levels, and FT3:FT4 ratio values were assessed at baseline, and incident hypertension (defined by blood pressure levels ≥ 140/90 mmHg) was estimated over a median of 8.
Article Synopsis
- The study explored the link between thyroid peroxidase antibodies (TPOAbs) and mortality, examining how sociodemographic and lifestyle factors influence TPOAb levels.
- Younger age, higher body mass index, female sex, and smoking habits were identified as key determinants of detectable and positive TPOAb levels among participants.
- Higher TPOAb levels were associated with increased cancer-related mortality risk in men and other causes of mortality in women, although the overall low mortality rate in the sample suggests a need for more research into the clinical significance of TPOAbs.