Publications by authors named "V McInerney"
Article Synopsis
- Long-QT syndrome type 3 (LQT3) is a cardiac ion channel disorder that increases the risk of dangerous heart rhythms, and this study aimed to create a model using human induced pluripotent stem cells (hiPSCs) to better understand the disease and test potential treatments.!
- Researchers generated hiPSCs from a patient with LQT3 and a healthy individual, employing CRISPR/Cas9 to introduce the same genetic mutation into healthy cells; all hiPSC lines were then converted into heart cells for analysis.!
- Both patient-derived and engineered LQT3 heart cells exhibited longer repolarization times, but treatments like mexiletine, nifedipine, and verapamil could effectively alter these
Purpose: In Ireland, over 3000 patients are diagnosed with breast cancer annually, and 1 in 9 Irish women will be diagnosed with breast cancer in their lifetime. There is evidence that female breast cancer survivors are more likely to die of cardiovascular disease than their age-matched counterparts. Specific services for cancer patients suffering from cancer therapy related cardiovascular toxicity have led to a higher incidence of safe anti-cancer treatment completion.
View Article and Find Full Text PDFVascular access device type for systemic anti-cancer therapies in cancer patients: A scoping review.
Crit Rev Oncol Hematol
April 2024
Background: Patients with cancer can expect to receive numerous invasive vascular access procedures for intravenous therapy and clinical diagnostics. Due to the increased incidence and prevalence of cancer globally there will be significantly more people who require first-line intravenous chemotherapy over the next ten years.
Methods: Our objective was to determine the types of evidence that exist for the vascular access device (VAD) type for the delivery of systemic anti-cancer therapy (SACT) in cancer patients.
Developmental and epileptic encephalopathies (DEEs) are a group of severe, early-onset epilepsies which are often caused by genetic mutations in ion channels. Mutations in KCNQ2, which encodes the voltage-gated potassium channel Kv7.2, is known to cause DEE.
View Article and Find Full Text PDFArticle Synopsis
- Mesenchymal stromal cells (MSCs) show potential as a new therapy for diabetic kidney disease (DKD), but clinical trials have faced challenges.
- In a phase 1b/2a trial involving 16 adults with type 2 diabetes, a low dose of MSCs (ORBCEL-M) was found to be safe and well-tolerated, with no serious adverse events linked to the treatment.
- Compared to a placebo group, those receiving ORBCEL-M experienced a significantly slower decline in kidney function, suggesting the need for further studies on this therapy.