NO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells.

Daily contact with considerable amounts of polystyrene nanoparticles (PSNPs) may cause harmful effects on the living organisms, through mechanisms that are not fully understood. The study aimed to evaluate the cytotoxic and genotoxic effects of PSNPs (size 200 nm and 40 nm) in mesenchymal stem cells (MSCs). In order to estimate cellular uptake and retention of nanoplastics, PSNP-treated cells have been analyzed by transmission electron microscopy.

Monitoring the Impact of Artificial Structure on Hydrogeological Environment: A Case Study of Hydraulic Tunnel at Pirot Hydropower Plant.

Artificial objects, particularly tunnels used for water transport under pressure, impact the geological and hydrogeological environment to a greater or lesser extent, and it is vital to assess their contributions to groundwater quality. Although tunnels are typically lined with concrete, their interaction with the hydrogeological environment intensifies over time. In this study, the detailed spatiotemporal monitoring of all hydrogeological features within the potential influence zone of the hydraulic tunnel of the Pirot Hydropower Plant has been conducted in order to determine the degree of interaction between the artificial object and the natural environment in real time, and to assess the correlation between monitored parameters.

Characterization and Environmental Evaluation of Recycled Aggregates from Construction and Demolition Waste in Belgrade City Area (Serbia).

Sustainable consumption of construction materials is an important segment of sustainable development goals towards reducing climate change. Since the consumption of natural aggregates raises environmental concerns, there is an increasing demand for use of recycled aggregates (RAs), as it enhances social and environmental benefits and creates a market opportunity. This paper presents the practice of using recycled construction and demolition waste (CDW) in the Belgrade city area (Serbia) as a resource.

Mesenchymal Stem Cell-Derived Extracellular Vesicles: New Soldiers in the War on Immune-Mediated Diseases.

Inflammatory diseases are a group of debilitating disorders with varying degrees of long-lasting functional impairment of targeted system. New therapeutic agents that will attenuate on-going inflammation and, at the same time, promote regeneration of injured organ are urgently needed for the treatment of autoimmune and inflammatory disorders. During the last decade numerous studies have demonstrated that crucial therapeutic benefits of mesenchymal stem cells (MSCs) in inflammatory diseases are based on the effects of MSC-produced paracrine mediators and not on the activity of engrafted cells themselves.

The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease.

Introduction: In the present study, we assessed the effects of the hyper-harmonized-hydroxylated fullerene-water complex (3HFWC) on Alzheimer's disease (AD) neuropathological hallmarks in 5XFAD mice, an AD animal model.

Methods: The 3-week-old 5XFAD mice were exposed to 3HFWC water solution ad libitum for 3 months in the presymptomatic phase of pathology. The functional effects of the treatment were confirmed through near-infrared spectroscopy (NIRS) analysis through machine learning (ML) using artificial neural networks (ANNs) to classify the control and 3HFWC-treated brain tissue samples.