Publications by authors named "V Mathews"
Granulocyte transfusions (GTx) combat infections in neutropenic patients. However, immune-mediated off-target effects in transplant settings are unknown. Between January 2020 and December 2021, all transplants that used GTx during the peri-transplant period were analysed.
View Article and Find Full Text PDFFungal Intracranial Infections (Central Nervous System-Invasive Fungal Disease) in Patients With Haematological Disorders-A Single-Centre Retrospective Study.
Mycoses
October 2024
Article Synopsis
- - Invasive fungal disease (IFD) in the central nervous system (CNS) poses a significant risk to patients with hematological disorders, leading to severe outcomes, especially in those undergoing chemotherapy or stem cell transplants.
- - A study analyzed 43 patients diagnosed with CNS-IFD from 2018 to 2022, identifying key clinical signs, such as sudden deterioration in sensorium, along with prevalent infections caused by Rhizopus and Aspergillus species.
- - The study revealed a low overall survival rate of 27.9% within six months, emphasizing the critical need for early diagnosis and timely antifungal treatment to improve patient outcomes.
Total marrow and lymphoid irradiation (TMLI) can deliver higher doses of irradiation without increased toxicity. This study evaluated TMLI and cyclophosphamide in patients undergoing stem cell transplantation for acute lymphoblastic leukemia (ALL). A total of 58 patients underwent matched related, unrelated, or haplo-identical donor transplantation using TMLI.
View Article and Find Full Text PDFIntroduction: International guidelines recommend definitive combination antibiotic therapy for the management of serious infections involving carbapenem-resistant Acinetobacter (CRAB) species. The commonly available combination options include high-dose sulbactam, polymyxins, tetracyclines, and cefiderocol. Scanty prospective data exist to support this approach.
View Article and Find Full Text PDFDuring the COVID-19 pandemic, our findings highlight changes in AML management strategies in India. There was a decrease in overall patient registrations, particularly at large referral centers, while smaller centers saw an increase, reflecting a shift towards more localized care. This shift was accompanied by a rise in the use of hypomethylating agents (HMAs).
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