Publications by authors named "V Martin Vazquez"
This study aimed to verify whether germline single nucleotide variants (SNV) in gene, c.-1765C>T, c.-1661A>G, c.
View Article and Find Full Text PDFMental health problems during childhood are associated with lowered educational attainment in adulthood. However, it is not clear if these associations hold when controlling for unobserved features of the family environment and if they depend on the socioeconomic status (SES) of parents. We use the Panel Study of Income Dynamics (PSID) Child Development and Transition into Adulthood Supplements (CDS; TAS) to examine these questions.
View Article and Find Full Text PDFCombined programmed cell death protein 1 and cytotoxic T-lymphocyte associated protein 4 blockade in an international cohort of patients with acral lentiginous melanoma.
Erin McGillivray Karam Ashouri Eftychia Chatziioannou Jesús Antonio Ocejo Gallegos Jabra Zarka Vinicius de Lima Vazquez
Br J Dermatol
January 2025
Article Synopsis
- Combination immune checkpoint blockade targeting PD-1 and CTLA-4 shows lower efficacy in acral lentiginous melanoma (ALM) compared to cutaneous melanoma (CM), with an objective response rate of only 18.3%.
- In a study of 109 patients, most had advanced cancer (stage IV), with median progression-free survival of 4.2 months and overall survival of 17 months.
- Significant treatment-related adverse events were common, indicating similar toxicity levels, but specific demographic factors like Asian ethnicity were linked to worse overall survival, highlighting the need for new treatment strategies for ALM.
Article Synopsis
- Lysosome positioning is essential for their functions and is influenced by amino acids, which can affect cell behavior, especially in cancer cells.
- In an analysis of 15 different amino acids, 10 were found to move lysosomes toward the cell edge, particularly aromatic amino acids, through specific transport mechanisms.
- The study also revealed that while some amino acids promoted lysosome movement, they didn’t activate the mTOR signaling pathway unless combined with others, and this effect was lessened in breast cancer cells when lysosomes couldn’t reach the cell periphery.
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with low survival rates, primarily treated through surgery and radiation, as highlighted by the Brazilian Society of Surgical Oncology's guidelines on its management.
- - The consensus emphasizes the importance of comprehensive staging, including imaging techniques like PET or CT scans, and recommends that all potential MCC cases be evaluated by a multidisciplinary team, including discussions in tumor boards to prevent treatment delays.
- - For early-stage patients (clinical stage I or II), local excision and sentinel lymph node biopsy are advised, while those with positive lymph nodes should receive radiation therapy, and advanced cases should consider participation in clinical trials for treatment options.