Objective: To verify changes in acoustic parameters, namely jitter, shimmer, and standard deviation of the fundamental frequency (dp f), through the life span of vocally healthy Brazilian Portuguese speakers.
Method: In total, 526 voice recordings of subjects without complaints and without vocal disorders, aged between 5 and 93 years old, were included. The recordings were divided into 12 age groups (5 to 7, 8 to 9, 10 to 11, 12, 13 to 15, 16 to 18, 19 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and 70 to 93 years old).
Calcium- and Integrin-Binding protein 2 (CIB2) is a widely expressed protein with an uncertain biological role. Two of its four EF-hand motifs bind Mg(II) and/or Ca(II), thus triggering conformational changes. Although previous studies suggested that CIB2 preferentially binds Mg(II) over Ca(II) under physiological conditions, an atomic level characterization of CIB2 in the presence of both cations was lacking.
View Article and Find Full Text PDFThe dimensions of objects and our body parts influence our perception of the weight of objects in our surroundings. It has been recently described a dramatic underestimation of the perceived weight of the hand. However, little is known on how perceived size informs the perceived weight of our own body parts.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
Guanylate Cyclase Activating Protein 1 (GCAP1) is a calcium sensor that regulates the enzymatic activity of retinal Guanylate Cyclase 1 (GC1) in photoreceptors in a Ca/Mg dependent manner. While point mutations in GCAP1 have been associated with inherited retinal dystrophies (IRDs), their impact on protein dimerization or on the possible interaction with the potent GC1 inhibitor RD3 (retinal degeneration protein 3) has never been investigated. Here, we integrate exhaustive in silico investigations with biochemical assays to evaluate the effects of the p.
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