Publications by authors named "V Marcel"
Elevated circulating levels of calprotectin (CAL), the S100A8/A9 heterodimer, are biomarkers of severe systemic inflammation. Here, we investigate the effects of CAL on early human hematopoiesis. CAL demonstrates limited impact on gene expression in stem and progenitor cells, in contrast with interleukin-6 (IL6), which promotes the expression of the and genes in hematopoietic progenitors and the generation of monocytes that release CAL.
View Article and Find Full Text PDFBackground: Brain tumors are the deadliest solid tumors in children and adolescents. Most of these tumors are glial in origin and exhibit strong heterogeneity, hampering the development of effective therapeutic strategies. In the past decades, patient-derived tumor organoids (PDT-O) have emerged as powerful tools for modeling tumoral cell diversity and dynamics, and they could then help defining new therapeutic options for pediatric brain tumors.
View Article and Find Full Text PDFEpithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological phenotypes. Using genome-wide analyses, we reported significant rearrangement of the translational landscape and machinery during EMT.
View Article and Find Full Text PDFEvaluation of bio-efficacy of field-aged novel long-lasting insecticidal nets (PBO, chlorfenapyr or pyriproxyfen combined with pyrethroid) against () in Tanzania.
Curr Res Parasitol Vector Borne Dis
September 2024
Article Synopsis
- Next-generation insecticide-treated bed nets (ITNs), which combine new insecticides or add synergists, are essential for fighting malaria, especially in regions with mosquito resistance to traditional pyrethroid nets.
- A study in Misungwi, Tanzania, tested the effectiveness of three types of these new nets over three years, comparing them against the standard Interceptor net; tests revealed they showed better efficacy against malaria-carrying mosquitoes.
- While over 80% of the new nets were effective after three years for susceptible mosquitoes, their effectiveness against resistant strains declined over time, indicating the need for ongoing research and potential replacements for long-term malaria control.
Cancer cells rely on high ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as "nucleolar stress" (NS), triggering p53-dependent and independent pathways leading to cell cycle arrest and/or apoptosis. The 5S ribonucleoprotein (RNP) particle, a sub-ribosomal particle, is instrumental to NS response.
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