OTULIN haploinsufficiency predisposes to environmentally directed inflammation.

Recently, OTULIN haploinsufficiency was linked to enhanced susceptibility to infections accompanied by local necrosis and systemic inflammation. The pathogenesis observed in haploinsufficient patients differs from the hyperinflammation seen in classical OTULIN-related autoinflammatory syndrome (ORAS) patients and is characterized by increased susceptibility of dermal fibroblasts to alpha toxin-inflicted cytotoxic damage. Immunological abnormalities were not observed in OTULIN haploinsufficient patients, suggesting a non-hematopoietic basis.

Deciphering the molecular functionality of Cdc45 in replisomal complex.

The members of DHH superfamily have been reported with diverse substrate spectrum and play pivotal roles in replication, repair, and RNA metabolism. This family comprises phosphatases, phosphoesterase and bifunctional enzymes having nanoRNase and phosphatase activities. Cell cycle factor Cdc45, a member of this superfamily, is crucial for movement of the replication fork during DNA replication and an important component of the replisome.

"IL-2 immunotherapy for targeting regulatory T cells in autoimmunity".

FOXP3 regulatory T cells (T) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of T biology. Consequences of defective IL-2 signalling are insufficient numbers or dysfunction of T and hence autoimmune disorders in human and mouse.

Regulatory T-cell stability and functional plasticity in health and disease.

FOXP3-expressing regulatory T cells (T ) are indispensable for immune homeostasis and tolerance, and in addition tissue-resident T have been found to perform noncanonical, tissue-specific functions. For optimal tolerogenic function during inflammatory disease, T are equipped with mechanisms that assure lineage stability. T lineage stability is closely linked to the installation and maintenance of a lineage-specific epigenetic landscape, specifically a T -specific DNA demethylation pattern.