Publications by authors named "V Malinova"
Disturbed cerebral autoregulation (CA) increases the dependency of cerebral blood flow (CBF) on cerebral perfusion pressure (CPP). Thus, induced hypertension (IHT) is used to prevent secondary ischemic events. The pressure reactivity index (PRx) assesses CA and can determine the optimal CPP (CPPopt).
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- Leucencephalopathy (LE) is common in elderly Parkinson's patients and can affect deep brain stimulation (DBS) surgery outcomes.
- A study of 135 Parkinson's patients found that 35.6% had LE, mostly mild to moderate, with no significant correlation to surgical complications or effectiveness of DBS treatment.
- The findings suggest that mild to moderate LE should not prevent patients from undergoing DBS surgery, as it does not increase risk or hinder motor function improvement post-surgery.
Aneurysmal subarachnoid hemorrhage (aSAH) not only causes neurological deficits but also influences extracerebral organ functions. The Logistic Organ Dysfunction System (LODS) reliably captures organ dysfunctions and predicts mortality of critically ill patients. This study investigated LODS in the setting of aSAH as a surrogate marker for early brain injury (EBI).
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- Early brain injury (EBI) after aSAH is linked to delayed cerebral ischemia (DCI), but there's currently no established method for assessing EBI severity.
- This study developed an EBI grading system using clinical signs and neuroimaging, including parameters like intracranial blood amount and persistent loss of consciousness.
- The grading system (from 1 to 5) was found to correlate with the risk of progressive global cerebral edema, need for surgical intervention, and overall patient outcomes.
Background/aim: Biomarkers for patients suffering from glioblastoma (GBM) are scarce. Extracellular vesicles (EV) are a promising candidate for a potential biomarker. Therefore, EV concentration could be a potential biomarker of tumor burden, volume, and prognosis.
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