[THE DIFFERENTIATED APPROACH TO PREVENTION OF NEURAL TUBE DEFECTS IN CHILDREN].

Neural tube defects occupy second place in frequency after the defects of the cardiovascular system. The folate metabolism violation and hyperhomocysteinemia in women are proved to be the leading risk factors for the NTD of the fetus. Polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) is a genetic determinant of folate metabolism violation.

[Dental status of patients with chronic diffuse diseases of the liver].

The intensity and prevalence of diseases of hard dental tissues and periodontium, correlation of serum, unstimulated mixed saliva, and gingival fluid biochemistry, and changes in the periodontal microcirculation were studied in 122 patients with chronic diffuse diseases of the liver. Specific changes in the biochemical parameters of unstimulated mixed saliva and gingival fluid in these patients were directly related to the biochemical parameters of the serum and the fact of dental treatment. Microcirculatory disorders in the distal portions of periodontal vessels (attached gingiva and gingival papilla) depended on local factors, while disorders in larger vessels of the buccal mucosa (transitional fold) were related to the severity of the underlying disease.