Publications by authors named "V Macias"
Unlabelled: While autoantibodies in bullous pemphigoid (BP) are known to activate the innate immune response, their direct effect on keratinocytes, and the contribution of BP-IgG autoantibody-dependent keratinocyte responses to BP pathology is largely unknown. Herein, we performed multiplex immunoassays and bulk RNA-seq on primary keratinocytes treated with IgG from BP patients or controls. We identified a pro-inflammatory and proteolytic response with release of several cytokines (IL-6, IL-24, TGF-β1), chemokines (CXCL16, CTACK, MIP-3β, RANTES), C1s, DPP4, and MMP-9.
View Article and Find Full Text PDFBackground: The model of obstetric care predominant in Mexico in most public and private healthcare institutions is particularly focused on a physiological perspective of the female body that does not respond to women's need for emotional comfort and satisfaction. In the last decade, however, various initiatives that provide obstetric care centered on women's rights have emerged.
Objective: To analyze the implementation of a model of humanized/respectful delivery care supervised by nursing and midwifery undergraduate interns in a birthing center in the state of Chiapas, in order to identify achievements and future challenges.
Article Synopsis
- The GI Tumors Workgroup of the Spanish Society of Radiation Therapy surveyed radiation oncologists in December 2020 to evaluate their adherence to international treatment guidelines for gastrointestinal tumors.
- The survey revealed a high level of adherence to standard treatments, with techniques like IMRT/VMAT being preferred for esophageal, gastric, pancreatic, and rectal cancers.
- Overall, the results indicate that radiation therapy practices in Spain are largely in line with international recommendations, emphasizing a commitment to evidence-based medicine.
Mosquitoes, like , are dipterans, the order of "true flies" characterized by a single set of two wings. are prime model organisms for biomedical research, while mosquito researchers struggle to establish robust molecular biology in these that are arguably the most dangerous vectors of human pathogens. Both insects utilize the RNA interference (RNAi) pathway to generate small RNAs to silence transposons and viruses, yet details are emerging that several RNAi features are unique to each insect family, such as how culicine mosquitoes have evolved extreme genomic feature differences connected to their unique RNAi features.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on improving gene editing techniques in a specific insect model that spreads Chagas disease, caused by parasites.
- Researchers tested methods to deliver CRISPR-Cas9 gene editing tools to female insects' developing eggs and confirmed these methods led to successful changes in eye and cuticle color.
- The findings pave the way for future gene editing in this insect species, potentially aiding the development of new strategies to control Chagas disease transmission.