[MODERN VIEWS ON THE PHARMACOGENETICS OF PAIN.].

Quality anesthesia during surgery and in the postoperative period remains a topical problem of modern anesthesiology. The study of genetic characteristics of a patient is a goal that may be allow us to develop a personalized approach to solve this problem. The purpose of the review is a synthesis of literature data about the influence of genetic factors on pain perception and its treatment.

[IMPROVING THE EFFICACY OF THERAPY FOR PATIENTS WITH MYOCARDIAL INFARCTION COMPLICATED BY CIRCULATORY FAILURE].

The effectiveness of drug remaxol inclusion in the scheme of treatment of patients with myocardial infarction on the background of degree III - III acute cardiac insufficiency was evaluated by the analysis of clinical and laboratory data of 126 patients with newly diagnosed acute myocardial infarction including ST-segment elevation on the background of acute cardiac insufficiency. Depending on the regimen, patients were divided into two groups. The first (control) group included 60 patients who received conventional thrombolytic therapy; the second (main) group included 66 patients which, after thrombolytic therapy, received remaxol (single daily intravenous administration, 400 mL at 3 - 4 mL/min rate) with controlled central venous pressure, arterial pressure, and diuresis.

[Monitoring of analgesia and amnesia during the general anesthesia in surgeries made on the lungs].

Somatosensorially evoked and auditorially evoked potentials (SSEP and AEP) were evaluated in 75 patients in different stages of general anesthesia during surgical procedures made on the lungs. N19-P23 latent increases of SSEP denoted an adequate level of analgesia. The AEP evaluation is recommended for monitoring the amnesia status during general anesthesia.

[Neuromediatorial mechanisms of analgesia during general anesthesia].

Neuromediatorial analysis with an evaluation of the EEG total bioelectric activity of the cortical and subcortical brain structures was performed in rabbits at general anesthesia variants. Naloxone, mu-opioid antagonist, johimbine, alpha2-adrenoceptor antagonist, metisergide, serotoninergic blocker were made use of. The leading role of adrenergic, a less important one of serotoninergic and a minimal one of opioid mechanisms are under discussion within the analgesia status during somatosensory nociception.