[CHARACTERISTICS OF THE RETINA IN CHRONIC STRESS IN LABORATORY RATS OF DIFFERENT AGE GROUPS].

The retina was studied in albino laboratory male rats of two age groups (12 and 24 months), 10 animals in each subjected to chronic combined stress. The stress was caused in animals by simultaneous exposure to pulsed light, loud sound, swinging and restriction of mobility for 7 days, 30 mm daily. The retina of intact rats of the corresponding age groups (n = 20) served as control.

[Alzheimer's disease and geriatric eye diseases in the aspect of amyloid genesis].

Geriatric eye diseases (age-related macular regeneration, pseudoexfoliation syndrome, pseudoexfoliative glaucoma, senile cataract) are one of the most important problems of modern ophthalmology. Meanwhile, the treatment of these diseases continues to be primarily empirically based for lack of not only valid data on their etiology, but even consensus of opinion on their pathogenesis. This review gives the current views on the commonness of the etiopathogenetic and morphological manifestations of Alzheimer's disease and age-related eye diseases in the aspect of amyloid genesis.

Immunohistochemical characteristics of the hypophysis in normal conditions and chronic stress.

Quantitative immunohistochemical methods were used to assess activation of the hypothalamo-hypophyseal-adrenocortical system at the level of its central component - the adenohypophysis - in the growing body during chronic exposure to psychoemotional stressors of different strengths. Sprague-Dawley rats aged 30 days were subjected to "mild" or "severe" immobilization stress for 5 h per day for seven days. Animals were decapitated at the end of the last stress session and the endocrine glands (hypophysis, adrenals) were harvested, weighed, and embedded in paraffin; sections were stained with hematoxylin and eosin, and also immunohistochemically using monoclonal antibodies to adrenocorticotropic hormone (ACTH) and proliferating cell nuclear antigen (PCNA) following by automated image analysis.

[Immunohistochemical characteristics of the hypophysis under normal and stress-associated conditions].

Quantitative immunohistochemical investigation was undertaken to detect the peculiarities of the activation of the hypothalamic-hypophyseal-adrenocortical system at the level of its central unit--the adenohypophysis--in the growing organism under the conditions of chronic exposure to psycho-emotional stressors of varying intensities. Sprague-Dawley rats aged 30 days were exposed to either mild or severe chronic restraint stress for 5 hours during seven consecutive days. After the last exposure to stress, rats were decapitated, the endocrine glands (pituitary and adrenal glands) were removed, weighted, and embedded in paraffin; histological sections were stained with hematoxylin and eosin.

Clinicopathological features and outcome of surgical treatment of 149 patients with early (pT1) gastric cancer.

Background: Controversy exists concerning the definition of, treatment approach to, prognostic factors of and survival data on early gastric cancer.

Patients And Methods: 149 patients who underwent curative gastrectomy for carcinoma between 1972 and 2002 and were classified as having early gastric cancer (T1Nany) were included into a retrospective study. Patients were followed for a median of 5.