Publications by authors named "V M Stoecklein"
First small sample studies indicate that disturbances of spinal morphology may impair craniospinal flow of cerebrospinal fluid and result in neurodegeneration. The aim of this study was to evaluate the association of cervical spinal canal width and scoliosis with grey matter, white matter, ventricular and white matter hyperintensity volumes of the brain in a large study sample. Four hundred participants underwent whole-body 3 T magnetic resonance imaging.
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- The study analyzed the survival characteristics of patients with IDH-mutant gliomas, comparing those who survived less than 6 years to those who lived at least 15 years.
- Factors linked to long-term survival included lower tumor grades, smaller tumor sizes, and strategies like "wait-and-scan," with female patients also having better outcomes.
- The findings suggest that larger tumor volumes and contrast enhancement are associated with shorter survival, while the wait-and-scan approach can lead to favorable long-term results, particularly in astrocytoma patients.
Purpose: This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs).
Methods: This retrospective, monocentric analysis included clinical data from all consecutive BM patients, who underwent simultaneous resection of ≥ 2 BMs between January 2018 and May 2023. Postoperative neurological and functional outcomes, along with perioperative complications, as well as survival data were evaluated.
Objective: The best treatment strategies for cerebral arachnoid cysts (CAC) are still up for debate. In this study, we present CAC management, outcome data, and risk factors for recurrence after surgical treatment, focusing on microscopic/endoscopic approaches as compared to minimally invasive stereotactic procedures in children and adults.
Methods: In our single-institution retrospective database, we identified all patients treated surgically for newly diagnosed CAC between 2000 and 2022.
Background: Treatment of hematological malignancies with chimeric antigen receptor modified T cells (CART) is highly efficient, but often limited by an immune effector cell-associated neurotoxicity syndrome (ICANS). As conventional MRI is often unremarkable during ICANS, we aimed to examine whether resting-state functional MRI (rsfMRI) is suitable to depict and quantify brain network alterations underlying ICANS in the individual patient.
Methods: The dysconnectivity index (DCI) based on rsfMRI was longitudinally assessed in systemic lymphoma patients and 1 melanoma patient during ICANS and before or after clinical resolution of ICANS.