Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.

Depletion of critical T cell subsets in vivo by treatment with anti-L3T4 antibody (mAb GK1.5) enables BALB/c mice to heal subsequent Leishmania major infection. To investigate the mechanisms by which healing is established, anti-leishmania cellular and humoral responses in anti-L3T4-treated BALB/c mice were compared to those in control BALB/c and genetically resistant C57BL/6 mice.