A New Era in Magnetic Resonance Contrast Media.

Next-generation gadolinium-based contrast agents (GBCAs), including both high relaxivity agents and targeted agents, and manganese-based agents with a high probably of commercial success are discussed in some depth. It is highly likely that gadopiclenol and gadoquatrane, both next-generation high relaxivity gadolinium-based compounds, will come in time to replace the current macrocyclic gadolinium chelates, despite the wide acceptance, very high safety profile, and high stability of the latter group. Current research has also made possible the development of 2 new targeted gadolinium chelates, which look very promising, with the potential to improve cancer detection (for both MT218 and ProCA32.

The Future Arrived: Photon-Counting Detector CT.

In the past decades, we have witnessed tremendous technical innovations in computed tomography (CT) imaging. These included improvements in temporal and spatial resolution, lowering of the radiation dose, the introduction of dual-energy and multi-energy imaging, automated image preprocessing and machine learning algorithms, and, most recently, the development and clinical introduction of photon-counting detector CT. This special issue of Investigative Radiology comprises a collection of expert summaries and reviews on this most impactful recent innovation and cutting-edge technology of photon-counting detector CT.

Scientific Advances and Technical Innovations in Musculoskeletal Radiology.

Decades of technical innovations have propelled musculoskeletal radiology through an astonishing evolution. New artificial intelligence and deep learning methods capitalize on many past innovations in magnetic resonance imaging (MRI) to reach unprecedented speed, image quality, and new contrasts. Similarly exciting developments in computed tomography (CT) include clinically applicable molecular specificity and substantially improved spatial resolution of musculoskeletal structures and diseases.