Association between serum levels of inflammatory mediators and periodontitis severity in people with down syndrome.

Evidence suggests that individuals with Down syndrome (DS) have a high prevalence of periodontal disease (PD). Factors such as muscular hypotonia, macroglossia, intellectual deficits, and reduced motor coordination, often combined with inadequate dietary habits, contribute to the development of PD. Additionally, a compromised immune response may explain the altered inflammatory profile that affects the systemic and oral health of this population.

A high-fat diet changes the interaction of the extracellular matrix, cytokines, and growth factors in gastric ulcer repair.

Background: Obesity is characterized by persistent low-grade inflammation that alters the gastrointestinal system and healing process. The link between obesity and the prevalence of stomach ulcers has not yet been fully established.

Aims: We investigated the healing features of gastric lesions in male Swiss mice fed a standard diet (SD) or high-fat diet (HFD) using morphometric, biochemical, and molecular parameters.

Long-term follow-up of the medial arch correction with calcaneal medialization osteotomy in progressive collapsing foot deformity.

Purpose: Medializing displacement calcaneal osteotomies are part of conservative surgical treatments and represent a reliable option in valgus flatfoot deformities. Favorable short-term results of this procedure is well-known. However, there are few series with follow-up beyond five years.

Mechanical Characterization of a Novel Cyclic Olefin-Based Hot-Melt Adhesive.

A novel hot-melt cyclic olefin-based adhesive was designed as a transparent, non-tacky film of amorphous thermoplastic with a unique polymer micro-structure. The aim of the present paper is to assess the mechanical properties of the 0.1 mm thick COP hot-melt adhesive film through adhesive characterizations tests.

Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from .

Sirtuin-2 (Sir2) is a histone deacetylase recognized as an antitrypanosomal target, yet there is limited knowledge regarding their potent inhibitors. This investigation employs the fragment-based drug discovery (FBDD) framework to identify novel inhibitors against Sir2-related protein 1. Initially, frequent residue-ligand interactions extracted from the crystallographic structures of human Sir2 and key features of human and parasitic Sir2 active sites were utilized to curate a targeted fragment library.