[Chromatin nuclear proteins in evaluation of the effectiveness of treatment of patients with psoriasis].

Histone proteins and nucleic acid precursors were studied in 10 normal subjects and 20 patients with disseminated psoriasis before and after combined therapy including Enkad. A drop in the concentrations of H1 histones was detected in the blood lymphocytes and plasma in parallel with an increase in the concentrations of arginine-rich histones and a many-fold decrease in the acid-soluble fraction representing a pool of nucleic acid precursors. After combined therapy the ratio of lysin- and arginine-rich nuclear proteins in blood lymphocytes changed significantly and approximated the normal value; the distribution of histone-like proteins virtually did not change in the plasma, but the level of plasma and erythrocyte acid-soluble fraction normalized.

[Lupus erythematosus: effects of different therapeutic methods on intranuclear characteristics of lymphoid cells].

In lymphocytes of peripheral blood from 46 patients with various forms of lupus erythematosus measurements were made of histone fractions and DNA. It is proved that intranuclear characteristics of lymphoid cells can be used in the choice of treatment and assessment of its efficacy. Lupus erythematosus treatment with glucocorticoids (diprospan, diprospan + celeston) is effective in correction of intranuclear lymphocyte changes in this disease.

[An analysis of the lymphoid cell histones in patients with different forms of lupus erythematosus].

The study was made of lisine- and arginine-rich histone fractions and DNA in lymphocytes of peripheral blood in patients with lupus erythematosus. The findings showed intranuclear changes of immunocompetent cells in various forms of the disease. The above parameters may be used in the diagnosis, evaluation of treatment efficacy, prognosis.

[Metabolism of nuclear proteins of the thymus and bone marrow cells in mice with hepatoma 22].

Specific characteristics of nuclear proteins synthesis were studied in thymus and bone marrow cells of mice with solid hepatoma 22, which enabled to find three main periods of alterations in the protein synthesis within 1-3 days, 5-9 and 11-13 days after administration of hepatoma 22. The most distinct alterations were observed within first day after the hepatoma 22 administration, which may be considered as a primary reaction of nuclear apparatus in the cells of tumor-bearing animals.