MICROSCOPIC CHANGES OF THE KIDNEY IN EXPERIMENTAL HYPERHOMOCYSTEINEMIA ON THE BACKGROUND OF HYPER- AND HYPOTHYROIDISM.

Hyper- and hypothyroidism are two typical clinical conditions that can cause a variety of metabolic changes, including impaired sulfur-containing amino acids metabolism, increased risk of cardiovascular disease, renal dysfunction, and renal failure. Hypothyroidism has been shown to be associated with increased serum creatinine, decreased glomerular filtration rate, and an increased risk of chronic kidney disease. At the same time, the pathophysiological mechanisms of renal dysfunction induced by excessive iodothyronine secretion are poorly understood.

CARDIOMYOCYTE DNA CONTENT AND ITS LINK TO CSE/ H2S SYSTEM IN THE HEART OF EXPERIMENTAL DIABETIC RATS.

One of the most common complication of diabetes mellitus (DM) is diabetic cardiomyopathy, which is associated with the development of inflammation, fibrosis and the induction of apoptosis. Hydrogen sulfide (H2S) has recently been shown to play an important role in the regulation of cardiac and vascular function. The role of the H2S system in the mechanisms of diabetic heart development remains uncertain.

INFLUENCE OF CHRONIC HYPERHOMOCYSTEINEMIA ON METABOLISM OF SULFUR CONTAINING AMINO ACIDS IN THE RATS' HEART AND BRAIN ON THE BACKGROUND OF HYPERTHYREOSIS AND HYPOTHYREOSIS.

The effect of experimental HHCy on the processes of transsulfuration of sulfur amino acids in the tissues of heart and brain, the levels of HCy, cysteine, H2S in blood serum of experimental animals with hyperthyroidism and hypothyroidism has been studied in the research. The experiment was performed on white male rats with simulated HHCy, hyper- and hypothyroidism, HHCy with different thyroid function. In the heart, the activity of cysteine aminotransferase (CAT), γ-glutamate cysteine ligase (γ-GCL), sulfite oxidase (SO) was determined.

THE STATE OF THE CYSTATHIONINE GAMMA-LYASE / H2S SYSTEM IN THE LIVER AND SKELETAL MUSCLES OF RATS WITH HYPERCHOLESTEROLEMIA UNDER SIMVASTATIN ADMINISTRATION.

In studies on 94 male Wistar rats changes in the hydrogen sulfide content (H2S) and cystathionine γ-lyase (CSE) in the liver and skeletal muscles in hypercholesterolemia under simvastatin treatment were assessed, as well as the effect of propargylglycine (PAG) on hepato- and myotoxicity of simvastatin. It was determined, that simvastatin inhibited the CSE-mediated synthesis of H2S in the main target organs. This negatively affected their biochemical and functional status.

SULPHUR-CONTAINING AMINO ACIDS METABOLISM IN EXPERIMENTAL HYPER- AND HYPOTHYROIDISM IN RATS.

Hyper- and hypothyroidism are some of the most common endocrinopathies that cause many metabolic disorders including amino acids metabolism. However, a specific molecular mechanism of thyroid hormones influence on sulphur-containing amino acids metabolism has not been established. The aim of our research was to investigate experimentally the influence of thyroid gland functional state on the main enzymatic systems of sulphur-containing amino acids metabolism in liver and kidneys, the content of homocysteine, cysteine and H2S in blood.