[The mechanism of the transport of organophosphorus compounds across the histo-hematic barriers].

It was demonstrated in experiments on mice [correction of rats] that the transport of organophosphorus compounds (OPC) through membranes of the histohematic barriers (HHB) of the organism occurs by means of diffusion. The rate of this process depends on the interaction of OPC with the specific sites of binding with the tissues, among which the enzyme carboxylesterase plays an important part. It is suggested that both the rate and direction of OPC diffusion are determined by the relationship between the values of affinity of the ligands for the sites of their specific binding found on both sides of the HHB.

[The medical aspects of the rehabilitation of patients with congenital heart defects and the problems of their social integration into modern society].

Treatment of 500 patients was used as a basis for the development of a complex stepwise programme of rehabilitation of patients with congenital heart diseases (CHD). It was noted that for a valuable social integration of people with CHD into the modern society it was necessary to perform not only the indicated, adequate and timely operations but also the inescapable measures for the improvement of their physical and psychophysiological adaptation. The following job in remote periods of observations of the patients operated upon must take into account its conformity to functional possibilities of energy expenditure for the chosen occupation and should be effected with the individually accessible (or indicated) level of the physical tension taken into consideration.

[Current aspects in the rehabilitation of patients with congenital heart defects].

Repeated examinations of patients with congenital heart diseases of "pale type" (33 patients operated upon and 20 patients not subjected to operations) were performed during continuous periods of observations. A stable rehabilitative effect was noted in the group of patients operated upon who retained their physical work capacity and adequate reactions of blood circulation and ventilation systems to physical exercise. While in men the level of physical work capacity was characterized by relative constancy, in women it had a clear tendency to elevation in the dynamics of continuous terms of observation.

[Sex differences in the rehabilitative effect in patients after the correction of congenital heart defects under long-term observation].

In the process of prolonged observations a clinical and special functional examination of 33 patients (13 men and 20 women) operated upon in childhood for congenital heart diseases of the "pale type" was performed. A stable rehabilitating effect was obtained after radical surgical treatment. At the same time it was found that the level of the maximum physical work ability was retained in greater degree in women as compared with men and was even a little greater when economically used in rest and under physical load at the expense of higher gas exchange efficiency of blood circulation.

[The importance of studying 11-HCS in determining the optimal times for the correction of congenital heart defects].

The hormonal reaction of the adrenal cortex to growing physical exercise was studied in 42 patients with congenital heart diseases and 54 healthy persons. The age of the people under examination was from 7 to 35 years. It was found that in response to submaximal physical exercise a reliable drop of glucocorticoid activity of the adrenals takes place in patients as early as at the period of the second childhood.