Deregulation mechanisms and therapeutic opportunities of p53-responsive microRNAs in diffuse large B-cell lymphoma.

Here, we have discussed the molecular mechanisms of p53-responsive microRNAs dysregulation in response to genotoxic stress in diffuse large B-cell lymphoma (DLBCL) patients. The role of micro ribonucleic acids (microRNAs) in p53-signaling cellular stress has been studied. MicroRNAs are the small non-coding RNAs, which regulate genes expression at post-transcriptional level.

Stationary striations in plasma, created by a short microwave pulse in a waveguide filled with a neutral gas.

It was observed experimentally that after crossing a waveguide filled with a neutral gas a short powerful microwave pulse leaves a periodic glow of plasma along the waveguide, persisting for several tens of nanoseconds. A theoretical model is presented which in combination with numerical simulations proposes a possible explanation for this phenomenon.

[The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression].

Objective: To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25-44 years in Novosibirsk.

Material And Methods: Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample of people aged 25-44 years from the population of the Oktyabrsky district of Novosibirsk (men =725, mean age 43.4±0.

[Genes of the circadian rhythm and sleep disorders in an open population of men aged 25-64 years (an epidemiological study under the WHO MONICA-PSYCHOSOCIAL program)].

Objective: To study an effect of polymorphisms of genes encoding circadian rhythm proteins () on sleep disorders in men aged 25-64 years.

Material And Methods: The general examination was carried out according to standard methods included in the WHO MONICA-psychosocial (MOPSY) program. The standard Jenkins questionnaire was used to study sleep disorders.

Frequency conversion, "superluminal" propagation, and compression of a powerful microwave pulse in propagating ionization front.

Frequency up-conversion (∼10%) and compression (almost twofold) of a powerful (≤250 MW) microwave pulse in the propagating ionization front produced by the pulse itself in a gas-filled waveguide, is investigated experimentally and analyzed theoretically. Pulse envelope reshaping and group velocity increase manifest themselves in a propagation of the pulse faster than in the empty waveguide. A simple one-dimensional mathematical model allows the adequate interpretation of the experimental results.