[Peculiarities of anesthesia and systemic hemodynamics in experiment with 30 days head-down immobilization of monkeys].

Two series of surgery (biopsy) were performed before and after 30-d head-down immobilization (HDI) of monkeys. The animals were anaesthetized by inhaled isoflurane. Effects of immobilization on systemic hemodynamics and the progress of anesthesia were evaluated.

[Long-term antiorthostasis (-90 degrees) of animals as a model of critical disorders of homeostasis].

The cardiovascular effect of head-down tilt (at an angle of -90 degrees) was investigated in 25 mongrel dogs exposed to general anesthesia, myorelaxation or pulmonary ventilation. Changes in the circulation and contractility parameters can be subdivided into three periods. At early stages of the exposure an increase in contractile function and hemodynamic changes typical of preload were seen.

[Comparative evaluation of pressure chamber training and high altitude adaptation to hypoxia in humans].

It was demonstrated that a 3-day pressure chamber training may increase the maximum tolerable "altitude" at rest from 8,600-8,900 m (depending on the onset rate of hypoxia) to 9,600 m. After pressure chamber training the maximum tolerable "altitude" increased from 8,200 m to 9,200 m, when exercising in a bicycle ergometer at 200 kgm/min and continuously ascending at a rate of 20 m/sec. A similar antihypoxic effect was also provided by a 7-day high altitude adaptation.